Ian Orchard
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E-mail:
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Room:DV3137
My current research concerns investigations into aminergic and peptidergic neurons in insects and other invertebrates, with a view to elucidating the properties underlying integration and regulation of the nervous system. Specific areas of study include electrical recording and intracellular staining of identified peptidergic and aminergic neurons; identification of neuroactive substances and their receptors using molecular biology, HPLC, RIA and immunohistochemistry; pharmacological properties of receptors; involvement of second messengers in mediating target responses; and the use of this information in the biorational design of pesticides. Systems of particular interest include those associated with FMRFamide-related peptides, diuretic and antidiuretic hormones, proctolin, octopamine, dopamine and serotonin.
Publications
Most Significant Contributions to Research; For more complete list see https://www.researchgate.net/profile/Ian_Orchard/contributions
Orchard, I., Lange, A.B. (2024) The neuroendocrine and endocrine systems in insects–Historical perspective and overview. Molecular and Cellular Endocrinology. 15;580:112108. https://doi.org/10.1016/j.mce.2023.112108.
Orchard, I., Al-Dailami, A., Leyria, J. and Lange, A. B. (2023) Malpighian tubules of Rhodnius prolixus: More than post-prandial diuresis. Frontiers in Insect Science, 3, 23. https://doi.org/10.3389/finsc.2023.1167889
Orchard, I., Leyria, J., Lange, A.B. (2022) The hormonal and neural control of egg production in the historically important model insect, Rhodnius prolixus: A review, with new insights in this post-genomic era. Gen. Comp. Endocrinol. 321-322: 114030. https://doi.org/10.1016/j.ygcen.2022.114030
Al-Dailami, A.N., Leyria, J., Orchard, I. and Lange, A.B. (2022) Exploring the role of glycoprotein hormone GPA2/GPB5 in the medically important insect, Rhodnius prolixus. Peptides 149: 170710. https://doi.org/10.1016/j.peptides.2021.170710
Orchard, I., Leyria, J., Al-Dailami, A., Lange, A.B. (2021) Fluid secretion by Malpighian tubules of Rhodnius prolixus: Neuroendocrine control with new insights from a transcriptome analysis. Front Endocrinol (Lausanne). 2021; 12: 722487. https://doi.org/10.3389/fendo.2021.722487