Angela Lange smiling in front of a building on the UTM campusm wearing a black blazer with a pink blouse underneath. She has short, grey hair.

Angela B. Lange

Professor Emeritus
Biology

My research interests lie within the field of insect reproductive physiology. In particular, I am interested in the means by which cells and tissues communicate with one another in order to produce integrated and coordinated output. To this end, I have developed a model system in which I have identified motor and modulatory input onto the oviducts of the locust, Locusta migratoria. These inputs must be coordinated in order to produce the correct response at the appropriate time (e.g. egglaying). This work entails neurophysiology, neurochemistry, receptor physiology and signal transduction. Work of this nature can furnish the means of controlling insect pests by development of new insecticides.

 

Publications

Examples of Significant Contributions to Research; For more complete list see https://www.researchgate.net/profile/Angela-Lange 

Orchard, I., Lange, A.B. (2024) The neuroendocrine and endocrine systems in insect–Historical perspective and overview. Molecular and Cellular Endocrinology. 15;580:112108. https://doi.org/10.1016/j.mce.2023.112108

Leyria, J., Guarneri, A.A., Lorenzo, M.G., Nouzova, M., Noriega, F.G., Benrabaa, S.A.M,, Fernandez-Lima, F., Tose, L.V., Orchard, I., Lange, A.B. (2023) Effects of mating on female reproductive physiology in the insect model, Rhodnius prolixus, a vector of the causative parasite of Chagas disease. PLoS Negl Trop Dis 17(9): e0011640. https://doi.org/10.1371/journal.pntd.0011640   

Al-Dailami, A.N., Lange, A.B., Orchard, I. (2023) Corticotropin-releasing factor-like diuretic hormone acts as a gonad-inhibiting hormone in adult female, Rhodnius prolixus. Frontiers in Endocrinology 14. https://doi.org/10.3389/fendo.2023.1279929

Lange, A.B., Kisana, A., Leyria, J., Orchard, I. (2023) The male reproductive system of the kissing bug, Rhodnius prolixus Stål, 1859 (Hemiptera: Reduviidae: Triatominae): arrangements of the muscles and the myoactivity of the selected neuropeptides. Insects 14, 324. https://doi.org/10.3390/insects14040324

Leyria, J., Benrabaa, S., Nouzova, M., Noriega, F.G., Tose, L.V., Fernandez-Lima, F., Orchard, I., Lange, A.B. (2023) Crosstalk between nutrition, insulin, juvenile hormone, and ecdysteroid signaling in the classical insect model, Rhodnius prolixus. Int. J. Mol. Sci. 2023, 24, 7. https://doi.org/10.3390/ijms24010007

Lange, A.B., Leyria, J., Orchard, I. (2022) The hormonal and neural control of egg production in the historically important model insect, Rhodnius prolixus: A review, with new insights in this post-genomic era. Gen. Comp. Endocrinol. 321-322: 114030. https://doi.org/10.1016/j.ygcen.2022.114030 

Leyria, J., Orchard, I., Lange, A.B. (2021) The involvement of insulin/ToR signaling pathway in reproductive performance of Rhodnius prolixus. Insect Biochem. Mol. Biol. 130:103526. https://hdoi:10.1016/j.ibmb.2021.103526 

Leyria, J., Orchard, I., and Lange, A.B. (2020) What happens after a blood meal? A transcriptome analysis of the main tissues involved in egg production in Rhodnius prolixus, an insect vector of Chagas disease. PLoS Neglected Tropical Disease 14(10):e0008516. https://doi.org/10.1371/journal.pntd.0008516